Observed Cost and Variations in Short Term Cost-Effectiveness of Therapy for Ischemic Stroke in Interventional Management of Stroke (IMS) III.
Identifieur interne : 000696 ( PubMed/Checkpoint ); précédent : 000695; suivant : 000697Observed Cost and Variations in Short Term Cost-Effectiveness of Therapy for Ischemic Stroke in Interventional Management of Stroke (IMS) III.
Auteurs : Kit N. Simpson [États-Unis] ; Annie N. Simpson [États-Unis] ; Patrick D. Mauldin [États-Unis] ; Yuko Y. Palesch [États-Unis] ; Sharon D. Yeatts [États-Unis] ; Dawn Kleindorfer [États-Unis] ; Thomas A. Tomsick [États-Unis] ; Lydia D. Foster [États-Unis] ; Andrew M. Demchuk [Canada] ; Pooja Khatri [États-Unis] ; Michael D. Hill [Canada] ; Edward C. Jauch [États-Unis] ; Tudor G. Jovin [États-Unis] ; Bernard Yan [Australie] ; Rüdiger Von Kummer [Allemagne] ; Carlos A. Molina [Espagne] ; Mayank Goyal [Canada] ; Wouter J. Schonewille [Pays-Bas] ; Mikael Mazighi [France] ; Stefan T. Engelter [Suisse] ; Craig Anderson [Australie] ; Judith Spilker [États-Unis] ; Janice Carrozzella [États-Unis] ; Karla J. Ryckborst [Canada] ; L Scott Janis [États-Unis] ; Joseph P. Broderick [États-Unis]Source :
- Journal of the American Heart Association [ 2047-9980 ] ; 2017.
Abstract
Examination of linked data on patient outcomes and cost of care may help identify areas where stroke care can be improved. We report on the association between variations in stroke severity, patient outcomes, cost, and treatment patterns observed over the acute hospital stay and through the 12-month follow-up for subjects receiving endovascular therapy compared to intravenous tissue plasminogen activator alone in the IMS (Interventional Management of Stroke) III Trial.
DOI: 10.1161/JAHA.116.004513
PubMed: 28483774
Affiliations:
- Allemagne, Australie, Canada, Espagne, France, Pays-Bas, Suisse, États-Unis
- Alberta, Caroline du Sud, Catalogne, District de Dresde, Maryland, Nouvelle-Galles du Sud, Ohio, Pennsylvanie, Saxe (Land), Utrecht (province), Victoria (État), Île-de-France
- Barcelone, Calgary, Dresde, Melbourne, Paris, Sydney, Utrecht
- Université de Calgary, Université de Melbourne, Université de Sydney
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Simpson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Healthcare Leadership and Management, Medical University of South Carolina, Charleston, SC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Sud</region></placeName><wicri:cityArea>Department of Healthcare Leadership and Management, Medical University of South Carolina, Charleston</wicri:cityArea></affiliation></author><author><name sortKey="Mauldin, Patrick D" sort="Mauldin, Patrick D" uniqKey="Mauldin P" first="Patrick D" last="Mauldin">Patrick D. Mauldin</name><affiliation wicri:level="2"><nlm:affiliation>Department of General Internal Medicine and Geriatrics, Medical University of South Carolina, Charleston, SC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Sud</region></placeName><wicri:cityArea>Department of General Internal Medicine and Geriatrics, Medical University of South Carolina, Charleston</wicri:cityArea></affiliation></author><author><name sortKey="Palesch, Yuko Y" sort="Palesch, Yuko Y" uniqKey="Palesch Y" first="Yuko Y" last="Palesch">Yuko Y. Palesch</name><affiliation wicri:level="2"><nlm:affiliation>Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Sud</region></placeName><wicri:cityArea>Department of Public Health Sciences, Medical University of South Carolina, Charleston</wicri:cityArea></affiliation></author><author><name sortKey="Yeatts, Sharon D" sort="Yeatts, Sharon D" uniqKey="Yeatts S" first="Sharon D" last="Yeatts">Sharon D. Yeatts</name><affiliation wicri:level="2"><nlm:affiliation>Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Sud</region></placeName><wicri:cityArea>Department of Public Health Sciences, Medical University of South Carolina, Charleston</wicri:cityArea></affiliation></author><author><name sortKey="Kleindorfer, Dawn" sort="Kleindorfer, Dawn" uniqKey="Kleindorfer D" first="Dawn" last="Kleindorfer">Dawn Kleindorfer</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati, OH.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Tomsick, Thomas A" sort="Tomsick, Thomas A" uniqKey="Tomsick T" first="Thomas A" last="Tomsick">Thomas A. Tomsick</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati, OH.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Foster, Lydia D" sort="Foster, Lydia D" uniqKey="Foster L" first="Lydia D" last="Foster">Lydia D. Foster</name><affiliation wicri:level="2"><nlm:affiliation>Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Sud</region></placeName><wicri:cityArea>Department of Public Health Sciences, Medical University of South Carolina, Charleston</wicri:cityArea></affiliation></author><author><name sortKey="Demchuk, Andrew M" sort="Demchuk, Andrew M" uniqKey="Demchuk A" first="Andrew M" last="Demchuk">Andrew M. Demchuk</name><affiliation wicri:level="4"><nlm:affiliation>Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, Seaman Family MR Research Centre, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, Seaman Family MR Research Centre, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Khatri, Pooja" sort="Khatri, Pooja" uniqKey="Khatri P" first="Pooja" last="Khatri">Pooja Khatri</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati, OH.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Hill, Michael D" sort="Hill, Michael D" uniqKey="Hill M" first="Michael D" last="Hill">Michael D. Hill</name><affiliation wicri:level="4"><nlm:affiliation>Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, Seaman Family MR Research Centre, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, Seaman Family MR Research Centre, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Jauch, Edward C" sort="Jauch, Edward C" uniqKey="Jauch E" first="Edward C" last="Jauch">Edward C. Jauch</name><affiliation wicri:level="2"><nlm:affiliation>Division of Emergency Medicine, Medical University of South Carolina, Charleston, SC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Sud</region></placeName><wicri:cityArea>Division of Emergency Medicine, Medical University of South Carolina, Charleston</wicri:cityArea></affiliation></author><author><name sortKey="Jovin, Tudor G" sort="Jovin, Tudor G" uniqKey="Jovin T" first="Tudor G" last="Jovin">Tudor G. Jovin</name><affiliation wicri:level="2"><nlm:affiliation>Stroke Institute, University of Pittsburgh Medical Center, Pittsburgh, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Stroke Institute, University of Pittsburgh Medical Center, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Yan, Bernard" sort="Yan, Bernard" uniqKey="Yan B" first="Bernard" last="Yan">Bernard Yan</name><affiliation wicri:level="4"><nlm:affiliation>Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Von Kummer, Rudiger" sort="Von Kummer, Rudiger" uniqKey="Von Kummer R" first="Rüdiger" last="Von Kummer">Rüdiger Von Kummer</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Diagnostic and Interventional Neuroradiology, University Hospital Dresden, Dresden, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Diagnostic and Interventional Neuroradiology, University Hospital Dresden, Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author><author><name sortKey="Molina, Carlos A" sort="Molina, Carlos A" uniqKey="Molina C" first="Carlos A" last="Molina">Carlos A. Molina</name><affiliation wicri:level="3"><nlm:affiliation>Neurovascular Unit, Department of Neurology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurovascular Unit, Department of Neurology, Hospital Universitari Vall d'Hebron, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Goyal, Mayank" sort="Goyal, Mayank" uniqKey="Goyal M" first="Mayank" last="Goyal">Mayank Goyal</name><affiliation wicri:level="4"><nlm:affiliation>Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, Seaman Family MR Research Centre, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, Seaman Family MR Research Centre, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Schonewille, Wouter J" sort="Schonewille, Wouter J" uniqKey="Schonewille W" first="Wouter J" last="Schonewille">Wouter J. Schonewille</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University Medical Center Utrecht and the Rudolph Magnus Institute of Neurosciences, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, University Medical Center Utrecht and the Rudolph Magnus Institute of Neurosciences, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Mazighi, Mikael" sort="Mazighi, Mikael" uniqKey="Mazighi M" first="Mikael" last="Mazighi">Mikael Mazighi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology and Stroke Center, Lariboisière Hospital, DHU NeuroVasc, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology and Stroke Center, Lariboisière Hospital, DHU NeuroVasc, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Engelter, Stefan T" sort="Engelter, Stefan T" uniqKey="Engelter S" first="Stefan T" last="Engelter">Stefan T. Engelter</name><affiliation wicri:level="1"><nlm:affiliation>Neurorehabilitation Unit, Department of Neurology, Basel University Hospital, University of Basel, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Neurorehabilitation Unit, Department of Neurology, Basel University Hospital, University of Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Anderson, Craig" sort="Anderson, Craig" uniqKey="Anderson C" first="Craig" last="Anderson">Craig Anderson</name><affiliation wicri:level="4"><nlm:affiliation>George Institute for Global Health, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>George Institute for Global Health, Royal Prince Alfred Hospital, University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Spilker, Judith" sort="Spilker, Judith" uniqKey="Spilker J" first="Judith" last="Spilker">Judith Spilker</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati, OH.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Carrozzella, Janice" sort="Carrozzella, Janice" uniqKey="Carrozzella J" first="Janice" last="Carrozzella">Janice Carrozzella</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati, OH.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Ryckborst, Karla J" sort="Ryckborst, Karla J" uniqKey="Ryckborst K" first="Karla J" last="Ryckborst">Karla J. Ryckborst</name><affiliation wicri:level="4"><nlm:affiliation>Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, Seaman Family MR Research Centre, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, Seaman Family MR Research Centre, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Janis, L Scott" sort="Janis, L Scott" uniqKey="Janis L" first="L Scott" last="Janis">L Scott Janis</name><affiliation wicri:level="2"><nlm:affiliation>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Broderick, Joseph P" sort="Broderick, Joseph P" uniqKey="Broderick J" first="Joseph P" last="Broderick">Joseph P. Broderick</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati, OH.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28483774</idno><idno type="pmid">28483774</idno><idno type="doi">10.1161/JAHA.116.004513</idno><idno type="wicri:Area/PubMed/Corpus">000C06</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C06</idno><idno type="wicri:Area/PubMed/Curation">000C03</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000C03</idno><idno type="wicri:Area/PubMed/Checkpoint">000C03</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000C03</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Observed Cost and Variations in Short Term Cost-Effectiveness of Therapy for Ischemic Stroke in Interventional Management of Stroke (IMS) III.</title><author><name sortKey="Simpson, Kit N" sort="Simpson, Kit N" uniqKey="Simpson K" first="Kit N" last="Simpson">Kit N. Simpson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Healthcare Leadership and Management, Medical University of South Carolina, Charleston, SC simpsonk@musc.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country><wicri:regionArea>Department of Healthcare Leadership and Management, Medical University of South Carolina, Charleston</wicri:regionArea><wicri:noRegion>Charleston</wicri:noRegion></affiliation></author><author><name sortKey="Simpson, Annie N" sort="Simpson, Annie N" uniqKey="Simpson A" first="Annie N" last="Simpson">Annie N. Simpson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Healthcare Leadership and Management, Medical University of South Carolina, Charleston, SC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Sud</region></placeName><wicri:cityArea>Department of Healthcare Leadership and Management, Medical University of South Carolina, Charleston</wicri:cityArea></affiliation></author><author><name sortKey="Mauldin, Patrick D" sort="Mauldin, Patrick D" uniqKey="Mauldin P" first="Patrick D" last="Mauldin">Patrick D. Mauldin</name><affiliation wicri:level="2"><nlm:affiliation>Department of General Internal Medicine and Geriatrics, Medical University of South Carolina, Charleston, SC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Sud</region></placeName><wicri:cityArea>Department of General Internal Medicine and Geriatrics, Medical University of South Carolina, Charleston</wicri:cityArea></affiliation></author><author><name sortKey="Palesch, Yuko Y" sort="Palesch, Yuko Y" uniqKey="Palesch Y" first="Yuko Y" last="Palesch">Yuko Y. Palesch</name><affiliation wicri:level="2"><nlm:affiliation>Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Sud</region></placeName><wicri:cityArea>Department of Public Health Sciences, Medical University of South Carolina, Charleston</wicri:cityArea></affiliation></author><author><name sortKey="Yeatts, Sharon D" sort="Yeatts, Sharon D" uniqKey="Yeatts S" first="Sharon D" last="Yeatts">Sharon D. Yeatts</name><affiliation wicri:level="2"><nlm:affiliation>Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Sud</region></placeName><wicri:cityArea>Department of Public Health Sciences, Medical University of South Carolina, Charleston</wicri:cityArea></affiliation></author><author><name sortKey="Kleindorfer, Dawn" sort="Kleindorfer, Dawn" uniqKey="Kleindorfer D" first="Dawn" last="Kleindorfer">Dawn Kleindorfer</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati, OH.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Tomsick, Thomas A" sort="Tomsick, Thomas A" uniqKey="Tomsick T" first="Thomas A" last="Tomsick">Thomas A. Tomsick</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati, OH.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Foster, Lydia D" sort="Foster, Lydia D" uniqKey="Foster L" first="Lydia D" last="Foster">Lydia D. Foster</name><affiliation wicri:level="2"><nlm:affiliation>Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Sud</region></placeName><wicri:cityArea>Department of Public Health Sciences, Medical University of South Carolina, Charleston</wicri:cityArea></affiliation></author><author><name sortKey="Demchuk, Andrew M" sort="Demchuk, Andrew M" uniqKey="Demchuk A" first="Andrew M" last="Demchuk">Andrew M. Demchuk</name><affiliation wicri:level="4"><nlm:affiliation>Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, Seaman Family MR Research Centre, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, Seaman Family MR Research Centre, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Khatri, Pooja" sort="Khatri, Pooja" uniqKey="Khatri P" first="Pooja" last="Khatri">Pooja Khatri</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati, OH.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Hill, Michael D" sort="Hill, Michael D" uniqKey="Hill M" first="Michael D" last="Hill">Michael D. Hill</name><affiliation wicri:level="4"><nlm:affiliation>Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, Seaman Family MR Research Centre, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, Seaman Family MR Research Centre, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Jauch, Edward C" sort="Jauch, Edward C" uniqKey="Jauch E" first="Edward C" last="Jauch">Edward C. Jauch</name><affiliation wicri:level="2"><nlm:affiliation>Division of Emergency Medicine, Medical University of South Carolina, Charleston, SC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Sud</region></placeName><wicri:cityArea>Division of Emergency Medicine, Medical University of South Carolina, Charleston</wicri:cityArea></affiliation></author><author><name sortKey="Jovin, Tudor G" sort="Jovin, Tudor G" uniqKey="Jovin T" first="Tudor G" last="Jovin">Tudor G. Jovin</name><affiliation wicri:level="2"><nlm:affiliation>Stroke Institute, University of Pittsburgh Medical Center, Pittsburgh, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Stroke Institute, University of Pittsburgh Medical Center, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Yan, Bernard" sort="Yan, Bernard" uniqKey="Yan B" first="Bernard" last="Yan">Bernard Yan</name><affiliation wicri:level="4"><nlm:affiliation>Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Von Kummer, Rudiger" sort="Von Kummer, Rudiger" uniqKey="Von Kummer R" first="Rüdiger" last="Von Kummer">Rüdiger Von Kummer</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Diagnostic and Interventional Neuroradiology, University Hospital Dresden, Dresden, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Diagnostic and Interventional Neuroradiology, University Hospital Dresden, Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author><author><name sortKey="Molina, Carlos A" sort="Molina, Carlos A" uniqKey="Molina C" first="Carlos A" last="Molina">Carlos A. Molina</name><affiliation wicri:level="3"><nlm:affiliation>Neurovascular Unit, Department of Neurology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurovascular Unit, Department of Neurology, Hospital Universitari Vall d'Hebron, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Goyal, Mayank" sort="Goyal, Mayank" uniqKey="Goyal M" first="Mayank" last="Goyal">Mayank Goyal</name><affiliation wicri:level="4"><nlm:affiliation>Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, Seaman Family MR Research Centre, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, Seaman Family MR Research Centre, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Schonewille, Wouter J" sort="Schonewille, Wouter J" uniqKey="Schonewille W" first="Wouter J" last="Schonewille">Wouter J. Schonewille</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, University Medical Center Utrecht and the Rudolph Magnus Institute of Neurosciences, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, University Medical Center Utrecht and the Rudolph Magnus Institute of Neurosciences, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Mazighi, Mikael" sort="Mazighi, Mikael" uniqKey="Mazighi M" first="Mikael" last="Mazighi">Mikael Mazighi</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology and Stroke Center, Lariboisière Hospital, DHU NeuroVasc, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology and Stroke Center, Lariboisière Hospital, DHU NeuroVasc, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Engelter, Stefan T" sort="Engelter, Stefan T" uniqKey="Engelter S" first="Stefan T" last="Engelter">Stefan T. Engelter</name><affiliation wicri:level="1"><nlm:affiliation>Neurorehabilitation Unit, Department of Neurology, Basel University Hospital, University of Basel, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Neurorehabilitation Unit, Department of Neurology, Basel University Hospital, University of Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Anderson, Craig" sort="Anderson, Craig" uniqKey="Anderson C" first="Craig" last="Anderson">Craig Anderson</name><affiliation wicri:level="4"><nlm:affiliation>George Institute for Global Health, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>George Institute for Global Health, Royal Prince Alfred Hospital, University of Sydney, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region><settlement type="city">Sydney</settlement></placeName><orgName type="university">Université de Sydney</orgName></affiliation></author><author><name sortKey="Spilker, Judith" sort="Spilker, Judith" uniqKey="Spilker J" first="Judith" last="Spilker">Judith Spilker</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati, OH.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Carrozzella, Janice" sort="Carrozzella, Janice" uniqKey="Carrozzella J" first="Janice" last="Carrozzella">Janice Carrozzella</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati, OH.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Ryckborst, Karla J" sort="Ryckborst, Karla J" uniqKey="Ryckborst K" first="Karla J" last="Ryckborst">Karla J. Ryckborst</name><affiliation wicri:level="4"><nlm:affiliation>Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, Seaman Family MR Research Centre, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, Seaman Family MR Research Centre, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author><author><name sortKey="Janis, L Scott" sort="Janis, L Scott" uniqKey="Janis L" first="L Scott" last="Janis">L Scott Janis</name><affiliation wicri:level="2"><nlm:affiliation>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Broderick, Joseph P" sort="Broderick, Joseph P" uniqKey="Broderick J" first="Joseph P" last="Broderick">Joseph P. Broderick</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati, OH.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati</wicri:cityArea></affiliation></author></analytic><series><title level="j">Journal of the American Heart Association</title><idno type="eISSN">2047-9980</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Examination of linked data on patient outcomes and cost of care may help identify areas where stroke care can be improved. We report on the association between variations in stroke severity, patient outcomes, cost, and treatment patterns observed over the acute hospital stay and through the 12-month follow-up for subjects receiving endovascular therapy compared to intravenous tissue plasminogen activator alone in the IMS (Interventional Management of Stroke) III Trial.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">28483774</PMID><DateCreated><Year>2017</Year><Month>05</Month><Day>09</Day></DateCreated><DateRevised><Year>2017</Year><Month>11</Month><Day>18</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2047-9980</ISSN><JournalIssue CitedMedium="Internet"><Volume>6</Volume><Issue>5</Issue><PubDate><Year>2017</Year><Month>May</Month><Day>08</Day></PubDate></JournalIssue><Title>Journal of the American Heart Association</Title><ISOAbbreviation>J Am Heart Assoc</ISOAbbreviation></Journal><ArticleTitle>Observed Cost and Variations in Short Term Cost-Effectiveness of Therapy for Ischemic Stroke in Interventional Management of Stroke (IMS) III.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">e004513</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1161/JAHA.116.004513</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Examination of linked data on patient outcomes and cost of care may help identify areas where stroke care can be improved. We report on the association between variations in stroke severity, patient outcomes, cost, and treatment patterns observed over the acute hospital stay and through the 12-month follow-up for subjects receiving endovascular therapy compared to intravenous tissue plasminogen activator alone in the IMS (Interventional Management of Stroke) III Trial.</AbstractText><AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">Prospective data collected for a prespecified economic analysis of the trial were used. Data included hospital billing records for the initial stroke admission and subsequent detailed resource use after the acute hospitalization collected at 3, 6, 9, and 12 months. Cost of follow-up care varied 6-fold for patients in the lowest (0-1) and highest (20+) National Institutes of Health Stroke Scale category at 5 days, and by modified Rankin Scale at 3 months. The kind of resources used postdischarge also varied between treatment groups. Incremental short-term cost-effectiveness ratios varied greatly when treatments were compared for patient subgroups. Patient subgroups predefined by stroke severity had incremental cost-effectiveness ratios of $97 303/quality-adjusted life year (severe stroke) and $3 187 805/quality-adjusted life year (moderately severe stroke).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Detailed economic and resource utilization data from IMS III provide powerful evidence for the large effect that patient outcome has on the economic value of medical and endovascular reperfusion therapies. These data can be used to inform process improvements for stroke care and to estimate the cost-effectiveness of endovascular therapy in the US health system for stroke intervention trials.</AbstractText><AbstractText Label="CLINICAL TRIAL REGISTRATION" NlmCategory="BACKGROUND">URL: http://www.clinicaltrials.gov. Registration number: NCT00359424.</AbstractText><CopyrightInformation>© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Simpson</LastName><ForeName>Kit N</ForeName><Initials>KN</Initials><AffiliationInfo><Affiliation>Department of Healthcare Leadership and Management, Medical University of South Carolina, Charleston, SC simpsonk@musc.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simpson</LastName><ForeName>Annie N</ForeName><Initials>AN</Initials><AffiliationInfo><Affiliation>Department of Healthcare Leadership and Management, Medical University of South Carolina, Charleston, SC.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mauldin</LastName><ForeName>Patrick D</ForeName><Initials>PD</Initials><AffiliationInfo><Affiliation>Department of General Internal Medicine and Geriatrics, Medical University of South Carolina, Charleston, SC.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palesch</LastName><ForeName>Yuko Y</ForeName><Initials>YY</Initials><AffiliationInfo><Affiliation>Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yeatts</LastName><ForeName>Sharon D</ForeName><Initials>SD</Initials><AffiliationInfo><Affiliation>Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kleindorfer</LastName><ForeName>Dawn</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati, OH.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tomsick</LastName><ForeName>Thomas A</ForeName><Initials>TA</Initials><AffiliationInfo><Affiliation>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati, OH.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Foster</LastName><ForeName>Lydia D</ForeName><Initials>LD</Initials><AffiliationInfo><Affiliation>Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Demchuk</LastName><ForeName>Andrew M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, Seaman Family MR Research Centre, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khatri</LastName><ForeName>Pooja</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati, OH.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hill</LastName><ForeName>Michael D</ForeName><Initials>MD</Initials><AffiliationInfo><Affiliation>Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, Seaman Family MR Research Centre, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jauch</LastName><ForeName>Edward C</ForeName><Initials>EC</Initials><AffiliationInfo><Affiliation>Division of Emergency Medicine, Medical University of South Carolina, Charleston, SC.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jovin</LastName><ForeName>Tudor G</ForeName><Initials>TG</Initials><AffiliationInfo><Affiliation>Stroke Institute, University of Pittsburgh Medical Center, Pittsburgh, PA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yan</LastName><ForeName>Bernard</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Melbourne Brain Centre, Royal Melbourne Hospital, University of Melbourne, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>von Kummer</LastName><ForeName>Rüdiger</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Institute of Diagnostic and Interventional Neuroradiology, University Hospital Dresden, Dresden, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Molina</LastName><ForeName>Carlos A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Neurovascular Unit, Department of Neurology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goyal</LastName><ForeName>Mayank</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, Seaman Family MR Research Centre, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schonewille</LastName><ForeName>Wouter J</ForeName><Initials>WJ</Initials><AffiliationInfo><Affiliation>Department of Neurology, University Medical Center Utrecht and the Rudolph Magnus Institute of Neurosciences, Utrecht, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>St. Antonius Hospital, Nieuwegein, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mazighi</LastName><ForeName>Mikael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology and Stroke Center, Lariboisière Hospital, DHU NeuroVasc, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Engelter</LastName><ForeName>Stefan T</ForeName><Initials>ST</Initials><AffiliationInfo><Affiliation>Neurorehabilitation Unit, Department of Neurology, Basel University Hospital, University of Basel, Basel, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University Center for Medicine of Aging, Felix Platter Hospital, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Anderson</LastName><ForeName>Craig</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>George Institute for Global Health, Royal Prince Alfred Hospital, University of Sydney, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spilker</LastName><ForeName>Judith</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati, OH.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carrozzella</LastName><ForeName>Janice</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati, OH.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ryckborst</LastName><ForeName>Karla J</ForeName><Initials>KJ</Initials><AffiliationInfo><Affiliation>Calgary Stroke Program, Departments of Clinical Neurosciences and Radiology, Seaman Family MR Research Centre, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Janis</LastName><ForeName>L Scott</ForeName><Initials>LS</Initials><AffiliationInfo><Affiliation>National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Broderick</LastName><ForeName>Joseph P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Departments of Neurology and Rehabilitation Medicine and Radiology, University of Cincinnati Gardner Neuroscience Institute University of Cincinnati Academic Health Center, Cincinnati, OH.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>Interventional Management of Stroke (IMS) III Investigators</CollectiveName></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>UL1 TR001450</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal 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MajorTopicYN="N">ischemic</Keyword><Keyword MajorTopicYN="N">stroke</Keyword><Keyword MajorTopicYN="N">stroke care</Keyword><Keyword MajorTopicYN="N">tissue‐type plasminogen activator</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>5</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>5</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>5</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28483774</ArticleId><ArticleId IdType="pii">JAHA.116.004513</ArticleId><ArticleId IdType="doi">10.1161/JAHA.116.004513</ArticleId><ArticleId IdType="pmc">PMC5524059</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Espagne</li><li>France</li><li>Pays-Bas</li><li>Suisse</li><li>États-Unis</li></country><region><li>Alberta</li><li>Caroline du Sud</li><li>Catalogne</li><li>District de Dresde</li><li>Maryland</li><li>Nouvelle-Galles du Sud</li><li>Ohio</li><li>Pennsylvanie</li><li>Saxe (Land)</li><li>Utrecht (province)</li><li>Victoria (État)</li><li>Île-de-France</li></region><settlement><li>Barcelone</li><li>Calgary</li><li>Dresde</li><li>Melbourne</li><li>Paris</li><li>Sydney</li><li>Utrecht</li></settlement><orgName><li>Université de Calgary</li><li>Université de Melbourne</li><li>Université de Sydney</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Simpson, Kit N" sort="Simpson, Kit N" uniqKey="Simpson K" first="Kit N" last="Simpson">Kit N. Simpson</name></noRegion><name sortKey="Broderick, Joseph P" sort="Broderick, Joseph P" uniqKey="Broderick J" first="Joseph P" last="Broderick">Joseph P. Broderick</name><name sortKey="Carrozzella, Janice" sort="Carrozzella, Janice" uniqKey="Carrozzella J" first="Janice" last="Carrozzella">Janice Carrozzella</name><name sortKey="Foster, Lydia D" sort="Foster, Lydia D" uniqKey="Foster L" first="Lydia D" last="Foster">Lydia D. Foster</name><name sortKey="Janis, L Scott" sort="Janis, L Scott" uniqKey="Janis L" first="L Scott" last="Janis">L Scott Janis</name><name sortKey="Jauch, Edward C" sort="Jauch, Edward C" uniqKey="Jauch E" first="Edward C" last="Jauch">Edward C. Jauch</name><name sortKey="Jovin, Tudor G" sort="Jovin, Tudor G" uniqKey="Jovin T" first="Tudor G" last="Jovin">Tudor G. Jovin</name><name sortKey="Khatri, Pooja" sort="Khatri, Pooja" uniqKey="Khatri P" first="Pooja" last="Khatri">Pooja Khatri</name><name sortKey="Kleindorfer, Dawn" sort="Kleindorfer, Dawn" uniqKey="Kleindorfer D" first="Dawn" last="Kleindorfer">Dawn Kleindorfer</name><name sortKey="Mauldin, Patrick D" sort="Mauldin, Patrick D" uniqKey="Mauldin P" first="Patrick D" last="Mauldin">Patrick D. Mauldin</name><name sortKey="Palesch, Yuko Y" sort="Palesch, Yuko Y" uniqKey="Palesch Y" first="Yuko Y" last="Palesch">Yuko Y. Palesch</name><name sortKey="Simpson, Annie N" sort="Simpson, Annie N" uniqKey="Simpson A" first="Annie N" last="Simpson">Annie N. Simpson</name><name sortKey="Spilker, Judith" sort="Spilker, Judith" uniqKey="Spilker J" first="Judith" last="Spilker">Judith Spilker</name><name sortKey="Tomsick, Thomas A" sort="Tomsick, Thomas A" uniqKey="Tomsick T" first="Thomas A" last="Tomsick">Thomas A. Tomsick</name><name sortKey="Yeatts, Sharon D" sort="Yeatts, Sharon D" uniqKey="Yeatts S" first="Sharon D" last="Yeatts">Sharon D. Yeatts</name></country><country name="Canada"><region name="Alberta"><name sortKey="Demchuk, Andrew M" sort="Demchuk, Andrew M" uniqKey="Demchuk A" first="Andrew M" last="Demchuk">Andrew M. Demchuk</name></region><name sortKey="Goyal, Mayank" sort="Goyal, Mayank" uniqKey="Goyal M" first="Mayank" last="Goyal">Mayank Goyal</name><name sortKey="Hill, Michael D" sort="Hill, Michael D" uniqKey="Hill M" first="Michael D" last="Hill">Michael D. Hill</name><name sortKey="Ryckborst, Karla J" sort="Ryckborst, Karla J" uniqKey="Ryckborst K" first="Karla J" last="Ryckborst">Karla J. Ryckborst</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Yan, Bernard" sort="Yan, Bernard" uniqKey="Yan B" first="Bernard" last="Yan">Bernard Yan</name></region><name sortKey="Anderson, Craig" sort="Anderson, Craig" uniqKey="Anderson C" first="Craig" last="Anderson">Craig Anderson</name></country><country name="Allemagne"><region name="Saxe (Land)"><name sortKey="Von Kummer, Rudiger" sort="Von Kummer, Rudiger" uniqKey="Von Kummer R" first="Rüdiger" last="Von Kummer">Rüdiger Von Kummer</name></region></country><country name="Espagne"><region name="Catalogne"><name sortKey="Molina, Carlos A" sort="Molina, Carlos A" uniqKey="Molina C" first="Carlos A" last="Molina">Carlos A. Molina</name></region></country><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="Schonewille, Wouter J" sort="Schonewille, Wouter J" uniqKey="Schonewille W" first="Wouter J" last="Schonewille">Wouter J. Schonewille</name></region></country><country name="France"><region name="Île-de-France"><name sortKey="Mazighi, Mikael" sort="Mazighi, Mikael" uniqKey="Mazighi M" first="Mikael" last="Mazighi">Mikael Mazighi</name></region></country><country name="Suisse"><noRegion><name sortKey="Engelter, Stefan T" sort="Engelter, Stefan T" uniqKey="Engelter S" first="Stefan T" last="Engelter">Stefan T. Engelter</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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